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USGS West Nile Virus Research Strategy

This plan integrates science across multiple USGS disciplines, and provides national and international opportunities for USGS collaboration with state and federal agencies, academic institutions, and non-governmental organizations throughout the Americas.

Fact Sheet

Effects of West Nile Virus

USGS scientists are embarking on bold new research to better understand the consequences this disease may have on wildlife and human health.

Fact Sheet

Safety and immunogenicity of poultry vaccine for protecting critically endangered avian species against highly pathogenic avian influenza virus, United States

In 2023, an outbreak of highly pathogenic avian influenza occurred among critically endangered California condors ( Gymnogyps californianus ), and > 21 died. We evaluated safety, immunogenicity, vaccination strategies, and correlates of antibody response of an influenza vaccine for poultry in black vultures ( Coragyps atratus ) and then California condors. We noted differences in antibody titers between vaccinated and unvaccinated birds (vultures p < 0.004; condors p­ < 0.02) but no adverse effects of vaccination. All vaccinated vultures and 80% of vaccinated condors showed maximum measured antibody response within the published range associated with survival of vaccinated and virally challenged chickens. We noted weak evidence of higher antibody responses for birds given two 0.5-mL vaccines versus those given one 1-mL vaccine but no correlation between antibody titers and sex for either species or between antibody titers and bone lead concentrations in vultures. Our results prompted initiation of a vaccination program for condors that could reduce spread of this disease among highly threatened species.

Emerging Infectious Diseases

Epidermal tumors of rainbow smelt with associated virus

Epithelial tumors of the skin occurred in landlocked populations of rainbow smelt ( Osmerus mordax ) in several lakes in New Hampshire (USA) during the spawning runs. Histologically, these were noninvasive epithelial cell lesions. Herpesvirus-like particles could be seen in the nucleus and cytoplasm. The lesions occurred in both males and females. Prevalence, which varied annually, was as high as 30%.

Journal of Wildlife Diseases