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USGS · 70018015

Bioconcentration of 5,5′,6 -trichlorobiphenyl and pentachlorophenol in the midge, Chironomus riparius, as measured by a pharmacokinetic model

M.J. Lydy·W. L. Hayton·A.E. Staubus·S.W. Fisher
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Abstract

A two compartment pharmacokinetic model was developed which describes the uptake and elimination of 5,5′,6-trichlorobiphenyl (TCB) and pentachlorophenol (PCP) in the midge, Chironomus riparius. C. riparius were exposed to nominal TCB (2 μg L −1 ) and PCP (9 μg L −1 ) concentrations during a 16 h static uptake phase. Depuration was determined over approximately 45 h using a flowthrough system without feeding. The uptake clearance (P) was 330±61 ml g −1 midge h −1 for TCB and 55±4 ml g −1 midge h −1 for PCP, while measured bioconcentration factors (BCF) were 35,900 and 458 for TCB and PCP, respectively. Overall, the clearance-volume-based pharmacokinetic model predicted BCF values that were consistent with published values as well as with BCF values obtained from the octanol-water partition coefficient (K OW ).

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M.J. Lydy, W. L. Hayton, A.E. Staubus, S.W. Fisher. 1994. Bioconcentration of 5,5′,6 -trichlorobiphenyl and pentachlorophenol in the midge, Chironomus riparius, as measured by a pharmacokinetic model. https://doi.org/10.1007/bf00224812

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