Isolation and identification of trichothecenes from Fusarium compactum suspected in the aetiology of a major intoxication of sandhill cranes

Richard J. Cole; Joe W. Dorner; John Gilbert; David N. Mortimer; Colin Crews; J.C. Mitchell; Ronald M. Windingstad; Paul E. Nelson; Horace G. Cutler

doi:10.1021/jf00084a009

USGS · 70006590

Isolation and identification of trichothecenes from Fusarium compactum suspected in the aetiology of a major intoxication of sandhill cranes

Richard J. Cole·Joe W. Dorner·John Gilbert·David N. Mortimer·Colin Crews·J.C. Mitchell·Ronald M. Windingstad·Paul E. Nelson·Horace G. Cutler

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Abstract

Isoneosolaniol (4,8-diacetoxy-12,13-epoxytrichothec-9-ene-3,15-diol) and other unidentified trichothecene mycotoxins were isolated from culture extracts of two highly toxigenic strains of Fusarium compactum cultured from waste peanuts involved in an acute intoxication of sandhill cranes ( Grus canadensis ). Neosolaniol and other unidentified trichothecenes were detected in waste peanuts collected from affected areas. The structure of isoneosolaniol was determined by 1 H and 13 C NMR analyses and by high-resolution mass spectometry. Isoneosolaniol was hightly toxic to 1-day-old chickens and to a HEp2 cell culture assay. It was concluded that the most logical cause of the sandhill crane intoxication was Fusarium spp. Contaminated peanuts and various trichothecene mycotoxins acting alone or in conjunction with other Fusarium mycotoxins.

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Journal of Agricultural and Food Chemistry Article

Source-reported bounding extent: 32.5215° to 32.961° latitude; -103.0637° to -102.2038° longitude. This indicates report coverage, not an exact sampling location. View area on OpenStreetMap.

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Richard J. Cole, Joe W. Dorner, John Gilbert, David N. Mortimer, Colin Crews, J.C. Mitchell, Ronald M. Windingstad, Paul E. Nelson, Horace G. Cutler. 2002-05-01. Isolation and identification of trichothecenes from Fusarium compactum suspected in the aetiology of a major intoxication of sandhill cranes. https://doi.org/10.1021/jf00084a009

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