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USGS · 5222281

Influence of the method of fluoride administration on toxicity and fluoride concentrations in Japanese quail

W. James Fleming·C.A. Schuler
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Abstract

Young Japanese quail ( Coturnix japonica ) were administered NaF for 16 d either in their diet or by esophageal intubation. Based on the total fluoride ion (Σmg F − ) intake over the 16-d experimental period, fluoride administered by intubation was at least six times more toxic than that fed in the diet. Dietary concentrations of 1,000 ppm F − (Σmg F − for 16 d = approx. 144) produced no mortality, whereas intubated doses produced 73% or greater mortality in all groups administered 54 mg F − /kg/d or more (Σmg F − for 16 d ≥ approx. 23 mg). Graphic comparison of the regression of log F − ppm in femurs/mg F − intake showed that fluoride levels in the femurs of quail administered fluoride by intubation were higher than in those administered fluoride in the diet.

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W. James Fleming, C.A. Schuler. 1988-10-01. Influence of the method of fluoride administration on toxicity and fluoride concentrations in Japanese quail. https://doi.org/10.1002/etc.5620071006

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