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K. G. Johnson

Publications and source records attributed to K. G. Johnson.

4 recordsLinked to original sources
USGS2006

Dietary exposure of largemouth bass to OCPs changes expression of genes important for reproduction

Dieldrin and p,p???-DDE are ubiquitous contaminants known to act as endocrine disruptors, causing impaired development and reproduction in fish and wildlife. In order to elucidate the mechanisms by which dieldrin and p,p???-DDE cause endocrine disruption in largemouth bass (Micropterus salmoides), fish were exposed subchronically through the diet to both contaminants. Following 120 days of exposure, p,p???-DDE decreased estradiol in females, but increased 11-ketotestosterone in both sexes. Dieldrin on the other hand, decreased estradiol and 11-ketotestosterone in both sexes. Both pesticides also altered steady state mRNA expression levels of a set of genes chosen to represent three possible mechanisms of endocrine disruption: (1) direct interaction with soluble sex steroid receptors, (2) biosynthesis of endogenous sex hormones, and (3) metabolism of endogenous hormones. p,p???-DDE acted as a weak estrogen, increasing the expression of vitellogenin and estrogen receptor ?? in the liver. p,p???-DDE also altered the expression of genes involved in the synthesis of endogenous hormones as well as their metabolism. Dieldrin, on the other hand, only altered expression of vitellogenin and not estrogen receptor ??. Dieldrin also altered the expression of genes involved in hormone synthesis and metabolism, and it dramatically lowered plasma hormone levels. Both pesticides targeted expression of genes involved in all three modes of action, suggesting that they each have multiple modes of action. ?? 2006 Elsevier B.V. All rights reserved.

Aquatic Toxicology↗
USGS1987

Hydraulic analyses of water-surface profiles in the vicinity of the Coamo Dam and Highway 52 bridge, southern Puerto Rico: Flood analyses as related to the flood of October 7, 1985

The magnitude, frequency and extent of the flood of October 7, 1985 at the Rio Coamo in the vicinity of the Coamo Dam and Highway 52 bridge in southern Puerto Rico, were investigated. The observed flood profiles were used to calibrate a step-backwater model. The calibrated model was then used to investigate several alternative flow conditions in the vicinity of the bridge. The peak discharge of the flood at the Highway 52 bridge was 72,000 cu ft/sec. This peak discharge was determined from the peak computed at a reach in the vicinity of the Banos de Coamo, about 1.2 mi upstream from the bridge. The computed discharge at the Banos de Coamo of 66,000 cu ft/sec was adjusted to the dam and bridge location by multiplying it by the ratio of the drainage areas raised to the 0.83 power. The flood had a recurrence interval of about 100 yr, exceeding all previously known floods at the site. The flood overtopped the spillway and levee of the Coamo Dam just upstream of Highway 52. The flow over the spillway was 54,000 cu ft/sec. Flow over the levee was about 18,000 cu ft/sec. About 10,000 cu ft/sec of the flow over the levee returned to the main channel at the base of the embankment at the northeast approach to the bridge. The remaining 8,000 cu ft/sec flowed south through the underpass on Highway 153. The embankment and shoulder on the northern span of the bridge were eroded with the eventual collapse of the approach slab.

Puerto Rico↗